The Grove Street Families is an African-American street gang and one of the oldest street gangs in Los Santos, San Andreas. They are the sworn enemy of the Ballas, an intense and ongoing rivalry as part of the Ballas-Grove Street War. Most of their territory can be found in the poorer/run-down neighborhoods in the far east of the city.They are easily identifiable by their green gang color. They are headed by Sean "Sweet" Johnson and lieutenants and OGs, Lance "Ryder" Wilson, Melvin "Big Smoke" Harris and Carl "CJ" Johnson. As far as street gangs in GTA San Andreas go, the GSF are depicted as more honorable than their rival gangs. Coming from a background of older traditions, they are against hard drugs being sold on their turf as opposed to the Ballas. They are very stubborn and Sweet refuses to adapt to changes in the Los Santos criminal underworld. They are well-known, however, for committing numerous other crimes and violent acts including gun running/arms-trafficking, gang-banging, gang warfare, murder, robbery, burglary/theft, gang-related homicide, vandalism and street violence. GSF members drive the Greenwood, Voodoo and Savanna. Their favourite radio station is the Radio Los Santos. They can be noticed around Ganton/Grove Street.

The Grove Street Families were formed in Ganton (initially in Grove Street) before spreading to the rest of Ganton and other neighborhoods. History before this time period (late 80's) is unknown, and much of what happened to the families during the late 80's is also unknown. However, what is known is that the Families are one of the oldest gangs in Los Santos - this possibly means that they are older than the Ballas (who formed during the 1970s) - giving the possibility that the Families evolved from the 1960s or even possibly earlier.
The Families also have a history of a traditional, intense, and bloody rivalry with the Ballas. Specifically when the gang war started is unknown, but the rivalry between the two gangs was in full swing as early as 1987.